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Film Compression Bandage

The film compression bandage is a new and unique modality to optimize the results of superficial foam sclerotherapy. Until modifications of the liners (layers required for storage and application of the film bandage) have not been fully performed according to dr. Ragg's patents, the application may be tricky if not unsatisfactory. This video shows how to use Tegaderm Roll (3M) to form a film compression bandage. May provide an impression of what it is about, but much too complex for daily use.



Valvuloplasty - Update 2017

Percutaneous valvuloplasty is the newest method to normalize diseased vein valves. It is applicable to all vein valves which are refluxive due to dilatation, with preserved and fully mobile vein cusps. The procedure includes a single local anesthesia and perivenous "no-touch" injection of a hyaluronan gel (some injected substance preceeds the path of cannula movement. In this example we see an impaired terminal GSV valve and a preterminal valve dilated, but still closing well during Valsalva test. This is typical for AAGSV insufficiency. Now, treatment of the AAGSV alone (e.g. thermal ablation) would expose the GSV to increased pressure (any deficite in valve function, congenital or acquired, will expose the next distal segment to increased pressure!). For this reason, it makes sense to go for a restoration of the terminal GSV valve. In the video, you see a 200 mm 27G cannula used for perivenous placement of hyaluronan, preferably first anterior (easier), then posterior to the target segment. With this substance (monophasic hyaluronan) just small canula movements to left and right positions are required. The video just shows a few seconds, in reality it took about 5 minutes to place 4 ml of hyaluronan. After that, in vertical position, no reflux was observed during Valsalva test. Even the restoration of the terminal valve cusps function could be monitored (B-scan). Summary: We are on a promising way to a very simple, safe, effective and adjustable modality for the restoration of refluxive vein valves. We just have to see the patients in initial stages.



Temporary and persistent blood cell aggregates

When looking at vein valves with high-resolution (HR), broad-band ultrasound systems, blood particle aggregations appear more intense. While some echoes represent typical low-flow aggregates (calles "sludge"), others seem to be stationary or fixed, resisting any flow acceleration, e.g. due to calf compression, foot movements, walking simulation or even tough physical exercise. We call them "motion-resistant aggregates" (MRA). These aggregates are neither velocity dependent like sludge nor are thy thrombus, which would show blood platelet aggregates and fibrin mesh. Once you know MRA, you will find them very frequently. MRA possibly correlate with inflammatory cusp infiltrations which are known for long from histology.



Hemodynamics and thrombus formation

This video shows a HR ultrasound of a femorosaphenal junction. We happened to see this floating, egg-shaped thrombus. This video nicely explains the relationship between venous stasis and thrombus: Within this GSV, there is stasis when the patient is standing or sitting, and GSV reflux already due to inspiration. As the proximal GSV is the most distal segment to be flushed by foot pump and calf musscle pump, there is a zone of maximal stasis, while the junction is sufficiently flushed by reflux and inflow from the superficial inferior epigastric vein. Thrombus formation occurs always in the area of maximum stasis. By the way, this situation was cured within minutes with an interventional procedure (laser coagulation), including the whole diseased vein, discharging the patient happily after two hours, without any danger of embolism and oral anticoagulant for just three days.



Vein valve dysfunction due to blood cell aggregates

This video shows one aspect of motion resistant aggregates (MRA): Both sinus are completely filled by MRA. The cusps look complete and rather tender and could be misinterpreted as regular. But during any motion, the cusps do NOT MOVE! There is reflux because the cusps are fixed. Total or partial cusp fixation by MRA is one of several ways of valve dysfunction. We look on an initial stage of venous insufficiency, usually not detected in daily practice.

Another potential mechanism of acquired vein valve damage is inflammatory degeneration ("sinus phlebitis").



Asymmetric valve damage

This video shows the two cusps of a GSV valve in a 34 year old female patient: One cusp looks almost normal (preserved structure, fully mobile, but moderate sclerosis) while the other one is crippled, immobile and associated to immobile blood cell aggregates. A single look does not reveal the genesis of this particular pathology, but even a congenital cusp lesion has to be considered. Longitudinal studies will help to explain if blood cell aggregates induce valve damage, or valve damage (sclerosis, immobility) rather induces particle aggregation. From today´s view, the first of these mechanisms seems do be dominant.



Floating Thrombus in the saphenofemoral junction

Case report: A 5 year-old male patient (former general practicioner) presented for ultrasound examination with large varicose veins. Incidentally, a floating egg-shaped thrombus was found at the right SFJ. Thrombus size was 14 x 7 x 6 mm, located in a clearly refluxive vein of 9 to 16 mm Ø. Due to threatening embolism, the decision was to go for immediate treatment. What would have been your recommendation? When presented at the German Angiology Congress Berlin 2017, the audience voted 50% for surgery and 50% for conservative treatment. But there is no reason for additional injury (surgery) or any risk of embolism (bandage + anticoagulation). Read the poster and enjoy the outcome!


Novel Biomatrix Sclerofoam

Biomatrix sclerofoam is a new modality of non-tumescent ablation. The foam is based on denatured blood proteins, providing a viscous and stable foam. Therefore, injections are more precise and more effective than with Cabrera-type foams or Varithena. The simplicity of biomatrix sclerofoam application may be best explained for a simple task like this, where it is easy even for a non-expert to follow tools and foam in the ultrasound image: Refluxive GSV below the knee, due to perforator inflow at proximal medial lower gel, furthermore there is relevant sidebranch insuffiency. The GSV at the thigh had been ablated 12 years ago by 810 nm laser and is no more detectable. First, after local anesthesia a venous access is positioned (maybe microcatheter or catheter for larger tasks). One ml of whole blood is taken, at this time to undergo a laboratory procedure, in future a small foam generator will be attached to the catheter. Foam is injected under strict ultrasound monitoring. The ultrasound volume has to cover ALL the potential distribution area, deep veins inclusive! Within seconds, the biomatrix foam is properly placed within all targets, including perforator and side branch. If you will, the puncture channel may be closed with a cheap bare fiber, but that´s luxury. No bandage needed. Finished! Larger three-dimensional targets like big recurrent varicosities may require some more effort and experience, but may be treated according to the same principle.

This video refers to the poster presentation:

Ragg JC: Floating thrombus at GSV junction - chance for instantaneous endovenous repair. A case report.


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About us

I have been working on innovations in venous medicine now for 17 years, together with my teams in Berlin, Munich and Zurich and a growing number of international friends.

My personal bio includes physics, interventional radiology, angiology, phlebology and meanwhile 27 years of clinical experience in interdisciplinary vascular medicine

Award Sponsors

All prizes are offered by the VENARTIS work group, from the private pocket of cooperating physicians.

The committee selecting the innovation award winner includes members of vWIN foundation and VENARTIS work group.


Work Group Dr. Ragg

c/o Swiss-VX Venentherapie
und Forschung GmbH
Chaltenbodenstrasse 16
CH - 8834 Schindellegi (SZ)
0041 - 79 938 95 71